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This modification alters the conformation and biological functions of target proteins

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Lastly, it is important to remark that ED could represent an early predictor of CV events and the diagnosis of vasculogenic ED at PDU, and particularly at dynamic PDU as the gold standard diagnostic tool, both in patients with or without additional CV risk factors and/or comorbidities, can help to recognize eventual arterial diseases in biggest distal vessels [35, 39,40,41]